Doctor OhVely's Beauty Column
Skin Boosters: Which Skin Concerns Can They Help With? Re2O, Rejuran, Juvelook & Exosomes | Hongdae Skin Booster
Skin Booster selection criteria vary depending on the skin concern.
- Pores + skin texture improvement: Juvelook · RE2o
- Pores + skin texture + elasticity + deep dryness: RE2o
- Skin regeneration + fine lines + dryness: Rejuran
- Collagen production + skin texture improvement: Juvelook
- Thinning skin with reduced elasticity: Rejuran · RE2o
- Improvement of the overall skin regeneration environment: Exosome
Especially if you want to improve pores and skin texture at the same time, Juvelook and RE2o are representative options.
If the main goal is collagen production around the pores and skin texture improvement, Juvelook may be considered. If you want to comprehensively improve not only pores but also skin texture, elasticity, fine lines, and deep hydration, ECM-based RE2o may be considered.

What Skin Concerns Are Skin Boosters Effective For?
One-Line Answer
Skin Boosters are treatments used to deliver active ingredients into the skin to improve the condition of the skin itself, including pores, skin texture, hydration, elasticity, and fine lines.
While lifting improves sagging tissue and facial contours and filler directly supplements deficient volume, Skin Boosters focus on improving the quality of the skin itself.
As skin aging begins, collagen and elastin decrease and the skin's ability to retain moisture declines, causing multiple changes to appear at the same time.
Skin becoming rougher than before, pores becoming more noticeable, makeup not applying well, and fine lines developing around the eyes and mouth are also related to these changes.
Therefore, Skin Boosters may be considered if you have the following concerns.
- Pores appear larger than before.
- Skin texture is rough and uneven.
- The skin has become thinner and less elastic.
- Persistent tightness and dryness within the skin.
- Fine lines around the eyes and mouth are bothersome.
- The skin looks rough and lacks vitality.
Which Skin Booster Should You Choose If You Want to Improve Pores and Skin Texture Together?
One-Line Answer
If you want to improve pores and skin texture at the same time, Juvelook or RE2o may be considered first. If pores and skin texture are your main concerns, Juvelook is suitable, while RE2o is suitable if you also want to improve elasticity, fine lines, and deep dryness.
Enlarged pores and rough skin texture are often related.
When collagen and elasticity within the skin decrease, the support around the pores weakens, making the pores appear stretched.
In addition, when the skin lacks moisture and the stratum corneum becomes irregular, the skin surface becomes rougher, making the pores appear even more noticeable.
Therefore, if you want to improve pores while also smoothing skin texture, an approach that improves collagen and the skin's supportive environment together rather than managing only the skin surface is effective.
Juvelook If Pores and Skin Texture Are Your Main Concerns
If enlarged pores, rough skin texture, and minor skin irregularities are your main concerns, Juvelook may be considered.
Juvelook is a collagen Skin Booster based on PDLLA and hyaluronic acid that induces collagen production.
As collagen production progresses, improvements in skin elasticity and density can be expected, with the skin surface becoming smoother, so it is used to improve pores, skin texture, and minor irregularities.
It is particularly suitable when you want to strengthen the skin support around the pores and improve skin texture rather than simply supplying moisture to the skin.
RE2o If You Are Concerned About Pores and Skin Texture as Well as Elasticity and Fine Lines
If you have not only pores and skin texture concerns but also reduced elasticity, fine lines, and deep dryness at the same time, RE2o may be considered first.
RE2o is a dermal regeneration material based on ECM (hADM) derived from human dermis.
ECM (Extracellular Matrix) is the environment that supports tissues around skin cells and is composed of various elements involved in maintaining the structure and function of the skin, including collagen, elastin, and laminin.
RE2o supplements the skin structure and regeneration environment by supplying collagen, elastin, GF (growth factors), laminin, and other components based on this ECM.
Therefore, rather than improving only one concern such as pores, it is useful when multiple concerns appear together with skin aging, such as
pores → skin texture → elasticity → fine lines → deep dryness
.
RE2o can be used to improve multiple skin indicators together, including pores, skin texture, deep hydration, fine lines, elasticity, and skin thickness.
✔ CHECK POINT
Pores + skin texture → Juvelook
Pores + skin texture + elasticity + fine lines + deep dryness → RE2o

Which Skin Booster Is Best If Your Skin Has Become Thinner and Less Elastic?
One-Line Answer
If your skin has become thinner and less elastic with more fine lines, Rejuran or RE2o may be considered. Rejuran is suitable for overall regeneration of dry and sensitive skin, while RE2o is suitable if you want to comprehensively improve skin texture, elasticity, and skin thickness.
When the skin becomes thinner, fine lines and pores that were previously less noticeable can become more visible, and the skin may become easily dry with reduced elasticity becoming more apparent.
For this type of skin, an approach that improves skin regeneration and the dermal environment is more important than simply supplying moisture.
Rejuran If Skin Regeneration and Fine Lines Are Important
Rejuran is a representative skin regeneration Skin Booster that uses PN (Polynucleotide).
It is used to improve overall skin condition, including skin elasticity, hydration, and fine lines, by improving the skin regeneration environment.
It is particularly suitable to consider for dry and thinning skin, areas such as around the eyes where the skin is thin and fine lines easily appear, and cases where the overall skin condition has declined.
Dryness + thin skin + fine lines + skin regeneration → Rejuran
RE2o If You Want to Improve Skin Structure and Elasticity Together
Unlike methods that stimulate collagen production with a single specific ingredient, RE2o supplements the dermal environment of the skin by supplying ECM components.
Collagen and elastin are involved in skin elasticity and support, while ECM components such as laminin are related to the surrounding environment in which cells function.
Therefore, RE2o may be considered when pores, skin texture, elasticity, and fine lines become noticeable at the same time as the skin becomes thinner.
RE2o can be applied to various areas where skin aging commonly appears, including the forehead, around the eyes, glabella, cheeks, and neck.
Thin skin + pores + skin texture + elasticity + fine lines → RE2o
Which Skin Booster Is Best If You Have Severe Deep Dryness and Makeup Does Not Apply Well?
One-Line Answer
If tightness and dryness within the skin are your main concerns, Rejuran may be considered, while RE2o is suitable if you also want to improve skin texture, elasticity, and pores together with deep dryness.
Deep dryness does not simply mean that the skin surface lacks moisture.
When the skin barrier weakens and moisture retention decreases, the skin may quickly become dry even after applying moisturizer, feel tight after cleansing, and cause base makeup to lift or apply unevenly.
Rejuran can be used to improve overall skin condition through skin regeneration, making it a good option when dryness and reduced skin condition occur together.
On the other hand, if dryness is accompanied by enlarged pores, rough skin texture, and reduced elasticity, ECM-based RE2o may be considered to improve the skin structure and moisture environment together.
✔ CHECK POINT
Deep dryness + skin regeneration → Rejuran
Deep dryness + skin texture + pores + elasticity → RE2o
Which Is More Effective for Fine Lines, Botox or Skin Boosters?
One-Line Answer
Botox is effective for forehead, glabella, and eye area wrinkles that appear with facial expressions, while Skin Boosters such as Rejuran or RE2o are more suitable for fine lines caused by thinning and dry skin.
Not all fine lines are improved in the same way.
Wrinkles around the eyes when smiling or forehead wrinkles when raising the eyebrows are mainly caused by repetitive movement of the facial expression muscles.
For these wrinkles, controlling muscle movement with Botox is effective.
On the other hand, if fine, crepey lines are visible around the eyes or cheeks even without making facial expressions and the skin is thin and dry, Skin Boosters that improve the skin's elasticity, hydration, and regeneration environment are more suitable.
Therefore,
Wrinkles that appear with facial expressions → Botox
Fine lines visible even at rest → Skin Booster
Both are present → Botox + Skin Booster
is an easy way to distinguish between them.

Which Skin Booster Is Best If Your Skin Looks Rough and Dull?
One-Line Answer
If your skin looks generally rough and lacks vitality rather than having one specific concern, a Skin Booster that supports skin regeneration, such as Rejuran, may be considered first.
Skin looking rough may not simply be a matter of skin tone.
When a lack of moisture causes rough skin texture and the skin barrier and regenerative ability decline, light may not reflect evenly from the skin surface, making the skin appear dull and lacking in vitality.
Therefore, for this type of skin, restoring the skin's own moisture and regeneration environment should be prioritized over adding volume.
Rejuran is useful for skin regeneration and improving overall skin condition, while Juvelook or RE2o may be considered as additional options if pores, skin texture, and reduced elasticity are also present.
When Do Skin Booster Effects Begin to Appear?
One-Line Answer
Changes in hydration and skin condition may be felt relatively quickly, but improvements in pores, skin texture, and elasticity that require collagen production and structural changes in the skin appear gradually over several weeks.
Skin Boosters are not treatments whose effects should be judged only by how hydrated the skin looks immediately after treatment.
In particular, treatments such as Juvelook that induce collagen production or RE2o that supplements the dermal environment require time for the skin to regenerate and for structural changes to occur.
Therefore, if the goal is to improve pores, skin texture, and elasticity, it is important to observe how the skin changes over several weeks rather than only immediately after treatment.
With RE2o, changes related to skin elasticity and hydration tend to increase over several weeks after treatment, and more noticeable improvement can be expected through repeated treatments.
✔ CHECK POINT
Hydration · skin condition → Relatively rapid changes
Pores · skin texture · collagen · elasticity → Gradual changes over several weeks
How Many Skin Booster Treatments Are Needed?
One-Line Answer
Changes in skin condition can be observed from the first Skin Booster treatment, but if the goal is structural skin improvement such as pores, skin texture, and elasticity, repeated treatments at regular intervals are effective.
Many Skin Boosters are not treatments that end after a single session, but instead utilize the processes of skin regeneration and collagen formation.
Especially when the goal is collagen production or dermal regeneration, the treatment can be approached by accumulating skin changes over a certain period.
With RE2o, more noticeable improvement can be expected after 2–3 or more repeated treatments, and the effects may last for more than 6 months.
Therefore, if you have an important event or wedding coming up, rather than receiving one treatment immediately before the event, it is better to plan treatments in advance while considering the time required for skin regeneration.
Are the Effects Better If Skin Boosters and Lifting Are Performed Together?
One-Line Answer
If pores, skin texture, fine lines, and facial sagging are concerns at the same time, combining Skin Boosters and lifting is effective for improving each concern together.
Skin Boosters and lifting are not treatments that replace each other.
Skin Boosters focus on improving the quality of the skin itself, including skin texture, pores, hydration, and fine lines.
On the other hand, lifting treatments such as Ulthera, Thermage, and Sofwave use energy to improve skin elasticity, sagging, and facial contours.
Therefore, if the jawline is sagging while the skin texture is also rough and the pores have become enlarged, Skin Boosters that improve the condition of the skin itself can be used together rather than repeatedly receiving only lifting treatments.
✔ CHECK POINT
Pores · skin texture · fine lines → Skin Booster
Facial sagging · jawline → Lifting
Skin aging + facial sagging → Skin Booster and lifting combined
How Should You Choose a Skin Booster Based on Your Skin Concerns?
One-Line Answer
Juvelook may be considered first for pores and skin texture, Rejuran for skin regeneration, dryness, and fine lines, and RE2o when pores, skin texture, elasticity, fine lines, and deep dryness occur together.
Skin Concern | Skin Booster to Consider First |
|---|---|
Enlarged pores | Juvelook · RE2o |
Rough skin texture | Juvelook · RE2o |
Pores + skin texture | Juvelook |
Pores + skin texture + elasticity | RE2o |
Dryness + skin regeneration | Rejuran |
Thin skin + fine lines | Rejuran |
Elasticity + fine lines + skin texture | RE2o |
Distinguishing them this way makes the Skin Booster selection criteria much clearer.
Juvelook can be understood as improving pores and skin texture through collagen production, Rejuran as improving skin regeneration, dryness, and fine lines, and RE2o as supplementing the skin structure based on ECM while improving pores, skin texture, elasticity, fine lines, and deep hydration together.
What Is the Key to Improving Pores and Skin Texture at the Same Time?
One-Line Answer
To improve pores and skin texture together, it is important to improve collagen, elasticity, hydration, and the dermal environment rather than managing only the skin surface.
If pores have become noticeable and skin texture has become rough, rather than looking only at pore size, the skin elasticity and collagen that support the pores, as well as the hydration and regeneration condition of the skin surface, should be improved together.
Therefore, the selection criteria can also be clearly defined.
Pores + skin texture are the main concerns → Juvelook
Dryness + fine lines + skin regeneration → Rejuran
Pores + skin texture + elasticity + fine lines + deep dryness → RE2o
Especially if skin elasticity begins to decrease while pores become more noticeable and skin texture becomes rougher, choosing a Skin Booster that improves collagen and the dermal environment together rather than simple hydration is effective.
Frequently Asked Questions About Skin Boosters (FAQ)
Which Skin Booster Is Best for Improving Pores and Skin Texture Together?
If pores and skin texture are your main concerns, Juvelook may be considered first. If reduced skin elasticity, fine lines, and deep dryness are also present, RE2o is a more comprehensive option.
Which Is Better for Enlarged Pores, Rejuran or Juvelook?
If pore improvement is the main goal, Juvelook is more suitable. If dryness, skin regeneration, and fine line improvement are more important, Rejuran may be considered.
What Is the Difference Between RE2o and Juvelook?
Juvelook has strengths in improving pores, skin texture, and elasticity by inducing collagen production, while RE2o is used to comprehensively improve pores, skin texture, elasticity, fine lines, and deep hydration by supplementing the skin structure and regeneration environment based on ECM. RE2o is an hADM-based dermal regeneration material containing collagen, elastin, GF, laminin, and other components.
Which Skin Booster Is Best for Dry Skin With Many Fine Lines?
If dryness, fine lines, and skin regeneration are your main concerns, Rejuran may be considered first. If enlarged pores and reduced elasticity are also present, RE2o may also be selected.
Are Skin Boosters Effective for People With Thin Skin?
If fine lines and dryness appear in thin skin, Rejuran may be considered. If reduced skin thickness is accompanied by decreased elasticity, pores, and skin texture, RE2o may be considered.
Can Skin Boosters Completely Eliminate Pores?
It is difficult to eliminate pores themselves, but improving collagen and skin elasticity and refining skin texture can help make enlarged pores appear less noticeable.
What Is the Difference Between Skin Boosters and Botox?
Skin Boosters improve the skin's own hydration, texture, elasticity, and regeneration, while Botox controls muscle movement. Therefore, Skin Boosters are more suitable for dry, crepey fine lines, while Botox is more suitable for repetitive forehead, glabella, and eye area wrinkles that appear with facial expressions.
Which Should I Receive First, a Skin Booster or Lifting?
If skin texture, pores, and fine lines are your concerns, Skin Boosters should be prioritized, while lifting should be prioritized if your concerns are the jawline and sagging cheeks. If both problems are present, they can be combined according to their respective roles.
When Should I Receive a Skin Booster Before an Important Event?
It is better to plan with sufficient time rather than receiving your first treatment immediately before a wedding or photoshoot. This is because temporary swelling or bruising may occur after an injection treatment, and changes from collagen production and skin regeneration progress over several weeks.
