Autologous Dermal Regeneration is a treatment that does not fill depressed areas with filler, but instead induces a regenerative response in the dermal layer to promote the formation of new collagen tissue.

Juvgen Autologous Dermal Regeneration involves the precise cross-injection of CO₂ gas and hyaluronic acid into the same area of the dermal layer. During this process, physical·chemical·biological stimulation occurs in the dermis, inducing the formation of new collagen tissue during the healing process.

It is particularly used for the following concerns.

Deep nasolabial folds → Autologous Dermal Regeneration

Clearly depressed wrinkles such as the glabella·forehead → Autologous Dermal Regeneration

Depressed acne scars → Autologous Dermal Regeneration

Old depressed scars → Autologous Dermal Regeneration

Volume deficiency over a wide area → Consider other volume treatments such as fillers·collagen boosters

The key is the difference between ‘filling by adding volume’ and ‘inducing new tissue to form within the dermis itself.’

What Is Autologous Dermal Regeneration?

Autologous Dermal Regeneration is a treatment that precisely cross-injects CO₂ gas and hyaluronic acid into the dermal layer to induce the skin's own collagen production response.

Deep wrinkles or depressed scars are not simply lines that form on the skin surface.

When wrinkles repeatedly form over a long period or skin tissue is damaged, the dermal structure itself can become depressed, creating deep grooves in the skin.

Autologous Dermal Regeneration directly targets this depressed dermal layer.

By precisely injecting CO₂ gas and hyaluronic acid, regenerative stimulation is created in the dermal tissue, inducing the formation of new collagen tissue during the subsequent healing process.

Therefore, unlike methods that lift wrinkles solely through the volume of an external substance, the key is to improve depressed areas with tissue produced by your own skin.

What Is Juvgen?

Juvgen is a method that precisely cross-injects CO₂ gas and hyaluronic acid in minute amounts to perform Autologous Dermal Regeneration with precision.

Juvgen directly targets the dermal layer where deep wrinkles or depressed scars are located.

In particular, it enables precise injections in units of 0.001cc and uses a structure that cross-injects CO₂ gas and hyaluronic acid.

The purpose is not simply to fill the depressed area with the volume of the injected substances themselves, but to induce a regenerative response in the area so that new collagen tissue is formed.

Therefore, rather than being a treatment that creates volume across the entire face, Juvgen is closer to a treatment that precisely improves deeply depressed lines or localized depressed areas.

Why Is Autologous Dermal Regeneration Effective for Deep Wrinkles?

Because deep wrinkles are not simply a surface skin problem but a structural change in which dermal tissue repeatedly folds and becomes depressed, treatments that directly induce collagen regeneration in the dermal layer can be used.

When facial expressions such as smiling or frowning are repeated, wrinkles that initially appear only during movement can eventually remain even when the face is at rest.

When collagen and elasticity decrease with skin aging, the grooves of the wrinkles become even deeper.

For wrinkles that have already become deeply established, reducing muscle movement with Botox may not be enough to fully smooth the grooves remaining in the skin.

Autologous Dermal Regeneration differs in that it induces collagen regeneration directly within this depressed dermal layer.

In other words,

Wrinkles that appear with facial expressions → Botox

Deep wrinkles that remain even at rest → Autologous Dermal Regeneration

Deep wrinkles + repetitive muscle movement → Consider Autologous Dermal Regeneration + Botox combination

can be approached in this way.

Is Autologous Dermal Regeneration Effective for Nasolabial Folds?

If a deep groove has formed within the skin itself along the nasolabial fold, Autologous Dermal Regeneration can be used to induce collagen regeneration in the depressed dermis.

Not all nasolabial folds are caused by the same factors.

In some cases, sagging cheeks cause the nasolabial area to fold, while in others, reduced facial volume causes the nasolabial area to appear depressed.

In contrast, repeated facial expressions over a long period can also create a deep groove along the nasolabial fold itself.

In such cases, an approach that directly improves the depressed wrinkle area may be necessary rather than simply lifting the entire face.

Nasolabial folds deepen due to sagging cheeks → Lifting

Nasolabial folds become prominent due to insufficient midface volume → Volume treatment

The nasolabial fold itself is deeply depressed → Autologous Dermal Regeneration

Sagging + deep nasolabial folds → Lifting + wrinkle treatment

Dividing the causes of nasolabial folds in this way makes it much clearer which treatment is needed.

Can Autologous Dermal Regeneration Be Used for Glabellar Wrinkles?

If deep lines remain between the eyebrows even without making facial expressions, Autologous Dermal Regeneration to regenerate the depressed dermis can be considered together with Botox.

Glabellar wrinkles are often caused by repeated movement of the muscles used when frowning.

In the early stages, the wrinkles appear only when making facial expressions, so reducing muscle movement with Botox is a direct approach.

However, when wrinkles are repeatedly formed over a long period, deep grooves can become established in the skin itself.

At this stage, even if muscle movement is reduced, the wrinkle lines that have already formed may remain.

Therefore,

Glabellar wrinkles that appear only with facial expressions → Botox

Deep glabellar wrinkles that remain even at rest → Autologous Dermal Regeneration

Deep glabellar wrinkles + strong muscle movement → Autologous Dermal Regeneration + Botox

can be divided according to the treatment purpose.

Can It Be Applied to Deep Forehead Wrinkles?

If deep horizontal static wrinkles remain on the forehead, Autologous Dermal Regeneration can be used to induce collagen regeneration in the dermal layer beneath the wrinkles.

Forehead wrinkles also initially appear and disappear depending on muscle movement.

However, as skin elasticity decreases and the same area repeatedly folds, the lines gradually deepen and remain even without making facial expressions.

For these static wrinkles, it is important to improve the already depressed skin structure in addition to simply reducing muscle movement.

However, the approach differs between cases where the entire forehead is depressed due to insufficient volume and cases where deep line-shaped wrinkles have formed.

Overall forehead volume deficiency → Volume treatment

Deep line-shaped forehead wrinkles → Autologous Dermal Regeneration

This distinction makes it easier to understand.

Is Autologous Dermal Regeneration Effective for Acne Scars?

For depressed acne scars where the skin is indented, Autologous Dermal Regeneration can be used to stimulate collagen production in the dermis beneath the scar and reduce its depth.

When acne causes severe inflammation, the dermal tissue can also become damaged.

If sufficient collagen is not produced during the subsequent healing process, the skin may not recover to its original level, leaving a depressed scar.

Autologous Dermal Regeneration does not simply fill these depressed areas with an external substance, but instead induces new tissue formation in the dermal layer beneath the scar.

It can be particularly useful for improving old depressed scars or localized deeply depressed scars.

Red acne marks → Vascular treatment

Brown acne marks → Pigmentation treatment

Widespread depressed scars·rough skin texture → Fractional laser

Localized deeply depressed scars → Autologous Dermal Regeneration

It is important to distinguish the concerns in this way.

What Is the Difference Between Fraxel and Autologous Dermal Regeneration?

Fraxel creates microscopic regenerative stimulation over a broad area of skin to improve overall scarring and skin texture, while Autologous Dermal Regeneration focuses on directly regenerating the dermis in specific deeply depressed areas.

Both treatments use collagen regeneration, but their approaches are different.

Fraxel creates microscopic treatment zones across the entire face or a broad area to induce skin remodeling.

Therefore, it is highly useful when multiple acne scars, enlarged pores, and rough skin texture are present together.

In contrast, Autologous Dermal Regeneration precisely treats scars or wrinkles that are deeply depressed in specific areas.

Therefore, using acne scars as an example,

Many shallow, widespread scars across the face → Fraxel

A few areas are particularly deeply depressed → Autologous Dermal Regeneration

Widespread scars + deep scars in specific areas → Consider Fraxel + Autologous Dermal Regeneration combination

can be divided in this way.

What Is the Difference Between Autologous Dermal Regeneration and Fillers?

Fillers fill depressed areas with the volume of the injected substance, while Autologous Dermal Regeneration induces collagen regeneration in the dermal layer so that your own tissue is formed.

The biggest difference is what creates the volume.

Fillers use injectable substances such as hyaluronic acid to immediately replenish deficient volume.

Therefore, they are useful for creating volume in relatively broad areas such as the cheeks·temples·front cheekbones.

In contrast, the hyaluronic acid used in Autologous Dermal Regeneration is not intended to create volume by injecting a large amount as with fillers. It is precisely injected together with CO₂ to induce a regenerative response in the dermis, improving depressed areas through the collagen tissue that subsequently forms.

In summary,

Want to immediately restore volume over a broad area → Filler

Want to improve deep line-shaped wrinkles → Autologous Dermal Regeneration

Want to improve localized depressed scars → Autologous Dermal Regeneration

The purposes differ in this way.

What Is the Difference Between Autologous Dermal Regeneration and Juvelook?

Both treatments utilize collagen production, but Juvelook injects collagen-stimulating ingredients over a broad area, while Autologous Dermal Regeneration directly targets deeply depressed areas to induce a regenerative response.

Collagen boosters such as Juvelook inject ingredients into the skin to stimulate collagen production over time.

Therefore, they can be used to improve pores·skin texture·fine lines or volume over a broad area.

Autologous Dermal Regeneration involves precisely injecting CO₂ and hyaluronic acid directly into the depressed dermal layer of wrinkles or scars.

Therefore, the selection criteria also differ.

Pores + skin texture + fine lines → Collagen booster

Natural increase in facial volume → Volumizing collagen booster

Deep nasolabial folds·glabellar wrinkles·forehead wrinkles → Autologous Dermal Regeneration

Localized deeply depressed scars → Autologous Dermal Regeneration

Do the Effects of Autologous Dermal Regeneration Appear Immediately?

Immediately after treatment, depressed areas may appear elevated due to the injection and tissue response, but the key changes from Autologous Dermal Regeneration gradually appear as collagen tissue forms afterward.

Autologous Dermal Regeneration is not a treatment that creates the final result solely through the volume of the injected substance, as fillers do.

Because swelling may occur after treatment, it is difficult to judge the final result based on the initial volume.

After the swelling subsides, the dermal healing process continues and new collagen tissue forms, gradually improving depressed wrinkles or scars.

Therefore, the tissue regeneration changes that appear over time are more important than the volume immediately after treatment.

Is One Autologous Dermal Regeneration Treatment Enough?

Changes can be expected even after one treatment, but additional treatments may be used depending on the depth of the wrinkles or degree of depression.

Because Autologous Dermal Regeneration utilizes the skin's regenerative response, it differs from maintenance-type treatments that are routinely repeated multiple times at short intervals.

For deep wrinkles or depressed scars, the regenerative process can be observed after one treatment, followed by additional treatment for areas that require further improvement.

Juvgen protocols involving additional treatments at intervals of approximately 1~2 months are also used.

How Long Does Swelling Last After Autologous Dermal Regeneration?

Swelling·redness·bruising may occur after treatment, and it is generally recommended to allow for a recovery period of several days to approximately one week.

Because Autologous Dermal Regeneration directly treats the dermal layer using a needle, it is not a treatment that leaves no visible signs immediately afterward.

In particular, when treatment is performed precisely along deep wrinkles or scars, the treated area may appear swollen or red.

Therefore, if you have an event where your face will be immediately visible, such as a wedding or important photo shoot, it is better to allow sufficient recovery time rather than receiving the treatment immediately beforehand.

What Are the Aftercare Instructions for Autologous Dermal Regeneration?

After treatment, it is recommended to avoid strong heat exposure, alcohol·smoking·strenuous exercise while swelling and bruising subside, and to avoid applying unnecessary pressure to the skin.

Do not strongly press or massage the treated area

Avoid strong heat exposure such as saunas·hot rooms

Avoid strenuous exercise during the recovery period

Avoid alcohol·smoking

Do not repeatedly touch areas with bruising or swelling

Maintain sun protection and basic moisturization

With Autologous Dermal Regeneration, the process in which the dermis heals stably and collagen tissue forms afterward is more important than the appearance immediately after treatment.

Who Is Autologous Dermal Regeneration Suitable For?

Autologous Dermal Regeneration is particularly useful when the goal is to improve ‘a specific deeply depressed area’ rather than creating volume across the entire face.

Simply put, it can be divided as follows.

The nasolabial fold itself is deeply depressed → Autologous Dermal Regeneration

Glabellar wrinkles remain clearly visible even at rest → Autologous Dermal Regeneration

Deep static wrinkles remain on the forehead → Autologous Dermal Regeneration

Localized deeply depressed acne scars → Autologous Dermal Regeneration

Old depressed scars → Autologous Dermal Regeneration

Wrinkles that appear only with facial expressions → Botox

Overall facial volume deficiency → Filler·Collagen Volume treatment

Widespread acne scars·pores·rough skin texture → Fractional treatment

Only specific areas within widespread scars are deeply depressed → Fractional treatment + Autologous Dermal Regeneration

The key to Autologous Dermal Regeneration is not to create shape by injecting a large amount of material into a depressed space, but to induce a regenerative response in the deeply depressed dermis so that new collagen tissue forms.

Therefore, it is a treatment with distinct characteristics when addressing ‘concerns where grooves have formed in the skin itself,’ such as long-standing, deeply established wrinkles in the nasolabial folds·glabella·forehead or localized depressed scars.

Autologous Dermal Regeneration FAQ

What Types of Wrinkles Are Most Suitable for Autologous Dermal Regeneration?

It is useful for deep static wrinkles that remain clearly visible even without making facial expressions. Areas where deep grooves have formed in the skin itself, such as the nasolabial folds·glabella·forehead·eye area, can be treated directly.

Is Autologous Dermal Regeneration Good for Shallow Fine Lines?

The characteristics of Autologous Dermal Regeneration can be better utilized when treating deeply depressed wrinkles in specific areas rather than shallow, widespread fine lines. If fine lines and skin texture are the main concerns, other methods such as skin boosters·radiofrequency·collagen boosters may be more suitable.

Which Is Better for Nasolabial Folds, Fillers or Autologous Dermal Regeneration?

If the nasolabial folds appear depressed due to volume deficiency, fillers may be considered. If the nasolabial fold itself is deeply depressed like a groove, Autologous Dermal Regeneration may be considered. If both concerns are present, each cause can be treated separately.

Is Botox Alone Enough for Glabellar Wrinkles?

Botox is a direct treatment for glabellar wrinkles that appear only when making facial expressions, but if deep lines remain even at rest, static wrinkles have already formed in the skin. In this case, an approach that treats muscle movement and the depressed wrinkles separately can be used.

Can It Be Used for Depressed Acne Scars?

Yes. Depressed scars where the skin is actually indented are one of the main indications for Autologous Dermal Regeneration.

Is It Effective for Red Acne Marks?

If only red marks remain, treatment targeting vascular redness is more direct than Autologous Dermal Regeneration. Autologous Dermal Regeneration focuses on scars where the skin structure itself is actually depressed rather than on color.

Can It Be Used for Deep Scars That Remain After Fraxel?

If overall skin texture has improved but certain scars remain deeply depressed, it can be used as a method to directly treat those depressed areas. Fraxel and Autologous Dermal Regeneration differ in their treatment areas and approaches.

Does Autologous Dermal Regeneration Lose Volume Immediately Like Fillers?

The mechanisms are different. Fillers create volume through the injected substance itself, while Autologous Dermal Regeneration utilizes the regenerative response of the dermis and the formation of new collagen tissue.

Can It Be Performed on the Entire Face?

Rather than being intended to create uniform volume across the entire face, it is more suitable for clearly defined treatment areas such as deeply depressed wrinkles or depressed scars.

How Often Should Autologous Dermal Regeneration Be Performed?

It is not a maintenance-type treatment that is continuously repeated at short intervals. After one treatment and the subsequent regenerative process, additional treatment may be performed at intervals of approximately 1~2 months if further improvement is needed.

Deep Wrinkles and Depressions: Are There Any Options Besides Fillers? From the Mechanism of Autologous Dermal Regeneration to Its Effects｜Hongdae Juvgen